Castor oil-citric acid copolyester for tissue augmentation

Diana E. Ickowicz, Moran Haim-Zada, Randa Abbas, Dan Touitou, Abraham Nyska, Ludmila Golovanevski, Carolyn F. Weiniger, Jeoshua Katzhendler, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Biodegrable polyesters derived from hydroxy acids have a broad clinical use. The aim of the study was to synthesize polymer compositions based on citric acid and castor oil for use as soft tissue augmentation. Two polymers were synthesized, a branched viscous polyester with a monomer ratio of 93.5:6.5 w/w and an apparent molecular weight of 11,000Da and a crosslinked semisolid polymer with a monomer ratio of 92.5:7.5 w/w. The branched polymer lost less than 10% of its weight during a 30-day degradation study. In vivo biocompatibility study in rats showed 20% formulation weight loss 9months post-subcutaneous administration. These results were in accordance with the in vitro hydrolytic degradation of the polymer. The in vivo study revealed good tolerability of the copolymer.

Original languageEnglish
Pages (from-to)1323-1328
Number of pages6
JournalPolymers for Advanced Technologies
Volume25
Issue number11
DOIs
StatePublished - 1 Nov 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 John Wiley & Sons, Ltd.

Keywords

  • Biodegradable polyester
  • Castor oil
  • Citric acid
  • Filler material
  • Soft tissue augmentation

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