Background: Music has long been used to ease symptoms of dementia. Several studies have shown the therapeutic benefits of music therapy to decrease symptoms of agitation in people with dementia (PWD). Other research has demonstrated that the use of music during caregiving can ease agitated behaviors. However, few studies have shown the clinical benefits of using translational research in practice between music therapists and certified nursing assistants. Introduction: We recruited 28 nursing home residents who were diagnosed with moderate to severe dementia to determine the effects of music therapy and music in aid of caregiving on symptoms of agitation. Methods: Participants were evaluated for agitation, then baseline assessments were completed 2 weeks apart. After the 2-week music therapy intervention, participants were evaluated immediately, 2 weeks post music therapy, and immediately following music in aid of caregiving. Results: A repeated measures analysis of variance (ANOVA) found that after 2 weeks of music therapy, agitation was significantly reduced and symptoms continued to decline following music in aid of caregiving. Conclusion: Results suggest that consideration for interdisciplinary use of music therapy and music in aid of caregiving should be considered to reduce and sustain symptoms of agitation in nursing home residents with dementia.