TY - JOUR
T1 - Candidate gene analysis in Israeli soldiers with stress fractures
AU - Yanovich, Ran
AU - Friedman, Eitan
AU - Milgrom, Roni
AU - Oberman, Bernice
AU - Freedman, Laurence
AU - Moran, Daniel S.
PY - 2012/3
Y1 - 2012/3
N2 - To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross-sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms-SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures). Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate-FDR). Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations.
AB - To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross-sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms-SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures). Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate-FDR). Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations.
KW - Bone remodeling
KW - Genetic variance
KW - Inherited predisposition
KW - SNPs
KW - Stress fractures
UR - http://www.scopus.com/inward/record.url?scp=84857829491&partnerID=8YFLogxK
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AN - SCOPUS:84857829491
SN - 1303-2968
VL - 11
SP - 147
EP - 155
JO - Journal of Sports Science and Medicine
JF - Journal of Sports Science and Medicine
IS - 1
ER -