Cancer incidence in a cohort of infertile women who underwent in vitro fertilization

Jehoshua Dor, Liat Lerner-Geva, Jaron Rabinovici, Angela Chetrit, David Levran, Bruno Lunenfeld, Shlomo Mashiach, Baruch Modan

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Objective: To assess whether ovarian hyperstimulation and IVF increase the risk for cancer. Design: Historical cohort analysis. Setting: IVF units of two medical centers in Israel. Patient(s): Five thousand twenty-six women who underwent IVF between 1981 and 1992.Intervention: Cancer incidence rates were determined through linkage to the National Cancer Registry and were compared with expected rates with respect to age, sex, and place of birth.Main Outcome Measure(s): Development of cancer. Result(s): Twenty-seven cases of cancer were observed, and 35.6 were expected (standardized incidence ratio, 0.76 [95% CI, 0.50-1.10]). Eleven cases of breast cancer were observed, whereas 15.86 were expected (standardized incidence ratio, 0.69 [95% CI, 0.46-1.66]). One case of ovarian cancer and 1 case of cervical cancer were observed, compared with 1.74 and 1.73 cases expected, respectively. The type of infertility, number of IVF cycles, and treatment outcome did not significantly affect risk for cancer. Conclusion(s): In a cohort of women treated with IVF, no excess risk for cancer was noted.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalFertility and Sterility
Volume77
Issue number2
DOIs
StatePublished - Feb 2002

Bibliographical note

Funding Information:
Partially supported by grant 3907/S from the Chief Scientist’s Ministry of Health, Jerusalem, Israel.

Funding

Partially supported by grant 3907/S from the Chief Scientist’s Ministry of Health, Jerusalem, Israel.

FundersFunder number
Chief Scientist’s Ministry of Health, Jerusalem, Israel

    Keywords

    • Cancer
    • In vitro fertilization
    • Infertility
    • Ovulation induction

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