Cancer Incidence in a Cohort of Infertile Women

Baruch Modan, Elaine Ron, Liat Lerner-Geva, Tzvia Blumstein, Joseph Menczer, Jaron Rabinovici, Gabriel Oelsner, Laurence Freedman, Shlomo Mashiach, Bruno Lunenfeld

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    235 Scopus citations


    Among 2,496 infertile Israeli women treated between 1964 and 1974, 143 cancer cases were observed as compared with 116.1 expected (standardized incidence ratio (SIR) = 1.2, 95% confidence interval (CI) 1.0-1.5) through 1991. Site-specific analysis revealed 12 ovarian cancers versus 7.2 expected (SIR = 1.6, 95% CI 0.8-2.9), 21 endometrial cancers versus 4.3 expected (SIR = 4.85, 95% CI 3.0-7.4), and 59 breast cancers versus 46.6 expected (SIR = 1.3, 95% CI 0.96-1.6). Sensitivity analysis revealed that confounding was unlikely to explain the raised risk of endometrial cancer, but nulliparity might explain the increased risk of ovarian cancer. The excess of endometrial cancer was prominent among patients with normal estrogen production but progesterone deficiency (SIR = 9.4, 95% CI 5.0-16.0). The risk for ovarian cancer was similar among the total groups of treated and untreated patients (SIR = 1.7 vs. 1.6). The standardized incidence ratio for endometrial cancer was higher among the treated group than the untreated group, although not significantly. Treatment with ovulation-inducing drugs does not appear to increase the risk for ovarian cancer, but its role cannot be completely excluded.

    Original languageEnglish
    Pages (from-to)1038-1042
    Number of pages5
    JournalAmerican Journal of Epidemiology
    Issue number11
    StatePublished - 1 Jun 1998


    • Breast neoplasms
    • Endometrial neoplasms
    • Infertility
    • Ovarian neoplasms
    • Ovulation induction


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