Cancer-associated fibroblasts in the single-cell era

Dor Lavie, Aviad Ben-Shmuel, Neta Erez, Ruth Scherz-Shouval

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations

Abstract

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes, origins and functions and consist of distinct subpopulations. Recent progress in single-cell RNA-sequencing technologies has enabled detailed characterization of the complexity and heterogeneity of CAF subpopulations in multiple tumor types. In this Review, we discuss the current understanding of CAF subsets and functions as elucidated by single-cell technologies, their functional plasticity, and their emergent shared and organ-specific features that could potentially be harnessed to design better therapeutic strategies for cancer.

Original languageEnglish
Pages (from-to)793-807
Number of pages15
JournalNature Cancer
Volume3
Issue number7
DOIs
StatePublished - Jul 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022, Springer Nature America, Inc.

Funding

A.B.-S. is supported by the Israel Cancer Research Fund (ICRF). N.E. is supported by the Department of Defense, Worldwide Cancer Research, the Israel Science Foundation and the ICRF. R.S.-S. is supported by the Israel Science Foundation, ERC starting grant 754320, the ICRF, the Laura Gurwin Flug Family Fund and the estate of David Levinson. R.S.-S. is the incumbent of the Ernst and Kaethe Ascher Career Development Chair in Life Sciences.

FundersFunder number
Laura Gurwin Flug Family Fund
U.S. Department of Defense
Israel Cancer Research Fund
Worldwide Cancer Research
European Research Council754320
Israel Science Foundation

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