Cancer-associated fibroblasts in the single-cell era

Dor Lavie; Aviad Ben-Shmuel; Neta Erez; Ruth Scherz-Shouval

doi:10.1038/s43018-022-00411-z

Cancer-associated fibroblasts in the single-cell era

Dor Lavie, Aviad Ben-Shmuel, Neta Erez, Ruth Scherz-Shouval

Research output: Contribution to journal › Review article › peer-review

286 Scopus citations

Abstract

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes, origins and functions and consist of distinct subpopulations. Recent progress in single-cell RNA-sequencing technologies has enabled detailed characterization of the complexity and heterogeneity of CAF subpopulations in multiple tumor types. In this Review, we discuss the current understanding of CAF subsets and functions as elucidated by single-cell technologies, their functional plasticity, and their emergent shared and organ-specific features that could potentially be harnessed to design better therapeutic strategies for cancer.

Original language	English
Pages (from-to)	793-807
Number of pages	15
Journal	Nature Cancer
Volume	3
Issue number	7
DOIs	https://doi.org/10.1038/s43018-022-00411-z
State	Published - Jul 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, Springer Nature America, Inc.

Funding

A.B.-S. is supported by the Israel Cancer Research Fund (ICRF). N.E. is supported by the Department of Defense, Worldwide Cancer Research, the Israel Science Foundation and the ICRF. R.S.-S. is supported by the Israel Science Foundation, ERC starting grant 754320, the ICRF, the Laura Gurwin Flug Family Fund and the estate of David Levinson. R.S.-S. is the incumbent of the Ernst and Kaethe Ascher Career Development Chair in Life Sciences.

Funders	Funder number
Laura Gurwin Flug Family Fund
U.S. Department of Defense
Israel Cancer Research Fund
Worldwide Cancer Research
European Commission	754320
Israel Science Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s43018-022-00411-z

Cite this

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Cancer-associated fibroblasts in the single-cell era

Abstract

Bibliographical note

Funding

UN SDGs

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