TY - JOUR
T1 - Can growth hormone increase, after clonidine administration, predict the dose of human menopausal hormone needed for induction of ovulation?
AU - Menashe, Y.
AU - Lunenfeld, B.
AU - Pariente, C.
AU - Frenkel, Y.
AU - Mashiach, S.
PY - 1990/3
Y1 - 1990/3
N2 - Recent observations claimed that growth hormone (GH) administration increased the sensitivity of the ovary to gonadotropin stimulation. These findings prompted us to assess whether ovarian response to human menopausal gonadotropin (hMG) is correlated to GH reserve. Before hMG administration, 25 patients were tested for GH reserve by administration of clonidine. Of the 25 patients, 8 showed a significant increase in GH (9.2 ± 4.5 ng/mL) and needed a significantly lower dose of hMG/human chorionic gonadotropin to elicit a good ovarian response than the 17 patients who did not respond to clonidine by GH increase (2.04 ± 1.2 ng/mL). Our results demonstrate that GH response to clonidine administration may help to estimate the initial dose range of hMB necessary for induction of ovulation.
AB - Recent observations claimed that growth hormone (GH) administration increased the sensitivity of the ovary to gonadotropin stimulation. These findings prompted us to assess whether ovarian response to human menopausal gonadotropin (hMG) is correlated to GH reserve. Before hMG administration, 25 patients were tested for GH reserve by administration of clonidine. Of the 25 patients, 8 showed a significant increase in GH (9.2 ± 4.5 ng/mL) and needed a significantly lower dose of hMG/human chorionic gonadotropin to elicit a good ovarian response than the 17 patients who did not respond to clonidine by GH increase (2.04 ± 1.2 ng/mL). Our results demonstrate that GH response to clonidine administration may help to estimate the initial dose range of hMB necessary for induction of ovulation.
UR - http://www.scopus.com/inward/record.url?scp=0025329859&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)53336-6
DO - 10.1016/s0015-0282(16)53336-6
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 2106450
AN - SCOPUS:0025329859
SN - 0015-0282
VL - 53
SP - 432
EP - 435
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -