C-reactive protein and atherothrombosis: Cause or effect?

Etty Grad, Haim D. Danenberg

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The complex relationship between the inflammatory response and vascular injury and repair is of major importance to the pathogenesis of cardiovascular disease. CRP is not only a strong marker for cardiovascular morbidity but a modulator that suppresses local and systemic thromboregulatory pathways. In the present review we address the question of whether CRP is involved in atherogenesis, in thrombosis, or in both components of the atherothrombotic process. While CRP is present in the atherosclerotic lesion, it is probably not pro-atherogenic and correlates only minimally with atherogenesis. Alas, CRP promotes thrombus formation and vascular occlusion. Thus, CRP is most likely not affecting atheroma build-up but rather the deleterious process of plaque vulnerability and thrombus formation. Dwelling into CRP mechanism of action may lead to the design of new diagnostic modalities that will add to the predictive value of CRP in identifying those patients at high cardiovascular risk. Furthermore, defining the mechanistic domain is the foundation to the cause-effect detection of possible therapeutic interventions to counter CRP morbid effects.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalBlood Reviews
Volume27
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Funding

This work was supported in part by BSF grant 2007240 to HDD and Israel Chief Scientist grant to HDD.

FundersFunder number
Bloom's Syndrome Foundation2007240
Chief Scientist Office

    Keywords

    • C-reactive protein
    • Cardiovascular disease
    • Endothelial dysfunction
    • Thrombosis

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