Butyrate Makes Macrophages “Go Nuclear” against Bacterial Pathogens

Lior Lobel; Wendy S. Garrett

doi:10.1016/j.immuni.2019.01.015

Butyrate Makes Macrophages “Go Nuclear” against Bacterial Pathogens

Lior Lobel, Wendy S. Garrett

Harvard University

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Butyrate is a microbial metabolite with pleiotropic effects. Schulthess et al. (2019) report that butyrate preconditioning of macrophages enhances their anti-bacterial preparedness by inducing anti-microbial proteins that restrict bacterial growth. This study augments understanding of how microbial metabolites shape host defense.

Original language	English
Pages (from-to)	275-278
Number of pages	4
Journal	Immunity
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2019.01.015
State	Published - 19 Feb 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Funding

W.S.G. is a member of the SABs of Kintai Therapeutics, Evelo Biosciences, and Leap Therapeutics. She has consulted for Pfizer Consumer Health, Merck, Celgene, and BiomX in the past two years.

Funders	Funder number
BiomX
Evelo Biosciences
Kintai Therapeutics
Pfizer Consumer Health
Merck
Celgene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.immuni.2019.01.015

Cite this

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abstract = "Butyrate is a microbial metabolite with pleiotropic effects. Schulthess et al. (2019) report that butyrate preconditioning of macrophages enhances their anti-bacterial preparedness by inducing anti-microbial proteins that restrict bacterial growth. This study augments understanding of how microbial metabolites shape host defense.",

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Butyrate Makes Macrophages “Go Nuclear” against Bacterial Pathogens

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

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