Butyrate-induced differentiation in leukemic myeloid cells: In vitro and in vivo studies

A. Rephaeli, J. Nordenberg, A. Aviram, E. Rabizadeh, Y. Zimra, A. Nudelman, A. Novogrodsky, M. Shaklai

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14 Scopus citations


A study of the effects of three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation and differentiation of primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA was an effective inhibitor of cell proliferation and inducer of cytodifferentiation. An acute non- lymphoblastic leukemia patient was treated with sodium butyrate. A temporary increase in differentiation-associated parameters were noted. However, the effects of SB were short-lived. The lack of clinical response led to the development of a BA prodrug pivaloyloxymethylbutyrate (AN-9). This prodrug was more potent in vitro than BA in the induction of cytodifferentiation and inhibition of cell proliferation.

Original languageEnglish
Pages (from-to)1387-1391
Number of pages5
JournalInternational Journal of Oncology
Issue number6
StatePublished - 1994
Externally publishedYes


  • ara-C
  • butyric acid
  • differentiation
  • proliferation
  • retinoic acid


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