Broadband macroscopic cortical oscillations emerge from intrinsic neuronal response failures

Amir Goldental, Roni Vardi, Shira Sardi, Pinhas Sabo, Ido Kanter

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Broadband spontaneous macroscopic neural oscillations are rhythmic cortical firing which were extensively examined during the last century, however, their possible origination is still controversial. In this work we show how macroscopic oscillations emerge in solely excitatory random networks and without topological constraints. We experimentally and theoretically show that these oscillations stem from the counterintuitive underlying mechanism—the intrinsic stochastic neuronal response failures (NRFs). These NRFs, which are characterized by short-term memory, lead to cooperation among neurons, resulting in sub- or several- Hertz macroscopic oscillations which coexist with high frequency gamma oscillations. A quantitative interplay between the statistical network properties and the emerging oscillations is supported by simulations of large networks based on single-neuron in-vitro experiments and a Langevin equation describing the network dynamics. Results call for the examination of these oscillations in the presence of inhibition and external drives.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalFrontiers in Neural Circuits
Issue numberOCTOBER
StatePublished - 30 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 Goldental, Vardi, Sardi,Sabo and Kanter.


  • Cortical oscillations
  • Neual networks
  • Neuronal plasticity
  • Neuronal response failures
  • Neuronal response latency


Dive into the research topics of 'Broadband macroscopic cortical oscillations emerge from intrinsic neuronal response failures'. Together they form a unique fingerprint.

Cite this