Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo

M. Hakim, R. Gonen, Z. Levitan, M. Sharf

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A prospective randomized placebo controlled double-blind study was conducted in order to evaluate the effect of short term perioperative antibiotic prophylaxis on patients undergoing elective abdominal hysterectomy. Fifty-two patients received 3 doses of 0.5 g cefazolin, 54 patients received 3 doses of 1 g mezlocillin and 53 patients received placebo. Postoperative infectious morbidity and the rate of pelvic cellulitis were significantly lower in either antibiotic group in comparison to the placebo group, but neither drug proved to be superior in this respect. The fever index was significantly lower in the mezlocillin group in comparison to both cefazolin and placebo groups. It was thus concluded that antibiotic prophylaxis has a beneficial effect on patients undergoing abdominal hysterectomy and both drugs - cefazolin and mezlocillin - seem to be equally effective.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume24
Issue number2
DOIs
StatePublished - Apr 1986
Externally publishedYes

Keywords

  • Elective abdominal hysterectomy
  • Evaluate effect of antibiotic prophylaxis
  • Placebo controlled double blind study
  • Postoperative infectious morbidity
  • Rate of pelvic cellulitis

Fingerprint

Dive into the research topics of 'Broad spectrum antibiotics as short term prophylaxis for elective abdominal hysterectomy: Comparison of mezlocillin, cefazolin and placebo'. Together they form a unique fingerprint.

Cite this