Brief electrical stimulation triggers an effective regeneration of leech CNS

Sharon Cohen, Alon Richter-Levin, Orit Shefi

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1 Scopus citations


The search for therapeutic strategies to promote neuronal regeneration following injuries toward functional recovery is of great importance. Brief low-frequency electrical stimulation (ES) has been reported as a useful method to improve neuronal regeneration in different animal models; however, the effect of ES on single neuron behavior has not been shown. Here, we study the effect of brief ES on neuronal regeneration of the CNS of adult medicinal leeches. Studying the regeneration of selected sets of identified neurons allow us to quantify.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
Issue number3
StatePublished - 1 May 2020

Bibliographical note

Funding Information:
Received January 23, 2019; accepted May 6, 2020; First published May 29, 2020. The authors declare no competing financial interests. Author contributions: S.C. and O.S. designed research; S.C. and A.R.-L. performed research; S.C. analyzed data; S.C. and O.S. wrote the paper. This work was partially supported by the Israel Science Foundation Individual Grant #1053/15. Acknowledgements: We thank Moshe Karni for his valuable help with the electrical stimulation setup and Gil Rudnitsky for his important advice with the fluorescence microscopy. Correspondence should be addressed to Orit Shefi at Copyright © 2020 Cohen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Publisher Copyright:
© 2020, Society for Neuroscience. All rights reserved.


  • CNS
  • Electrical stimulation
  • Glial cells
  • Medicinal leech
  • Regeneration
  • Single cell


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