Brain multiparametric responses to carbon monoxide exposure in the aging rat

A. Mendelman, N. Zarchin, J. Rifkind, A. Mayevsky

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10 Scopus citations

Abstract

The multiparametric monitoring system was applied to study the effects of 2000 ppm carbon monoxide (CO) on brain functions in vivo in the aging rat. The vasodilatory (non hypoxic) effects of CO on CBF in normal adult rats, which were shown in concentrations of 1000-2000 ppm involved the effect of nitric oxide (NO). Energy metabolism was evaluated by optical monitoring of CBF and mitochondrial function by fluorometry of NADH. Ionic homeostasis was evaluated by monitoring the extracellular level of K+ and H+ and the DC steady potential. Seven aging rats (24 months) were exposed to 2000 ppm for 60 min and 120 min of recovery, while five control rats were exposed to air under the same conditions. A comparison between the CO group and the control group showed that the changes in CBF, NADH and light reflectance were not statistically significant while extracellular K+ was elevated and tissue pH became more acidic. Thus, the typical CO induced increase in CBF, was not recorded in the aging rats. We concluded that the brain vasodilatory response to CO was not active in the aging rat, while the ionic homeostasis responses were similar to those found in the adult rat. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalBrain Research
Volume867
Issue number1-2
DOIs
StatePublished - 9 Jun 2000

Bibliographical note

Funding Information:
This study was supported by a grant from the Committee for Research and Prevention in Occupational Safety and Health, Ministry of Labor and Social Affairs, Israel; by the Ministry of Science and Technology, Israel; and by the National Institute of Environmental Health Sciences Grant R29-ES-05211.

Keywords

  • Aging rat
  • Carbon monoxide effect
  • Cerebral blood flow
  • Extracellular K
  • Mitochondrial redox state

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