TY - JOUR
T1 - Brain iron
T2 - A lesson from animal models
AU - Yehuda, S.
AU - Youdim, M. B.H.
AU - Hill, J. M.
AU - Levitsky, D. A.
PY - 1989/9
Y1 - 1989/9
N2 - Brain and blood iron deficiency (ID) can be nutritionally induced. Significant behavioral and brain-biochemical changes are observed in rats rendered iron deficient, including complete reversal of the circadian cycles of motor activity, changes in thermoregulation and stereotyped behavior, and an increased pain threshold. The increase in pain threshold is affected by diurnal factors and peripheral treatment with β-endorphin has a significant analgesic effect, implicating selective changes in the blood-brain barrier. These effects along with modifications in responses to dopaminergic drugs, interactions of ID with neuroleptic drugs, and modifications in behavior as a result of selective brain lesions, lead to two conclusions: this animal model is appropriate for human anemia and the best explanation for the variety of behavioral and brain biochemical changes in ID rats is that the principal effect of brain ID is a selective decrease in the functional level of the dopaminergic D2 system.
AB - Brain and blood iron deficiency (ID) can be nutritionally induced. Significant behavioral and brain-biochemical changes are observed in rats rendered iron deficient, including complete reversal of the circadian cycles of motor activity, changes in thermoregulation and stereotyped behavior, and an increased pain threshold. The increase in pain threshold is affected by diurnal factors and peripheral treatment with β-endorphin has a significant analgesic effect, implicating selective changes in the blood-brain barrier. These effects along with modifications in responses to dopaminergic drugs, interactions of ID with neuroleptic drugs, and modifications in behavior as a result of selective brain lesions, lead to two conclusions: this animal model is appropriate for human anemia and the best explanation for the variety of behavioral and brain biochemical changes in ID rats is that the principal effect of brain ID is a selective decrease in the functional level of the dopaminergic D2 system.
UR - http://www.scopus.com/inward/record.url?scp=0024467247&partnerID=8YFLogxK
U2 - 10.1093/ajcn/50.3.618
DO - 10.1093/ajcn/50.3.618
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C2 - 2570524
AN - SCOPUS:0024467247
SN - 0002-9165
VL - 50
SP - 618
EP - 629
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3 SUPPL.
ER -