Borophene Quantum Dots with Enhanced Nanozymatic Activity for the Detection of H2O2 and Cardiac Biomarkers

Syed Rahin Ahmed, Masoomeh Sherazee, Poushali Das, Jesse Dondapati, Seshasai Srinivasan, Amin Reza Rajabzadeh

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Quantum dots with unconventional properties can bring massive opportunities in multidirectional applications. Herein, borophene quantum dots (BQDs) have been synthesized that exhibit nanozymatic activity in addition to their conventional fluorescence emission nature and antibacterial activity. Fluorescence emission peak position and decay time were 450 nm and 2.8 ns, respectively. The average size of the BQDs was 5.2 nm. A significant 5-fold enhancement of the nanozymatic activity of BQDs was observed through an electrochemical process that enabled H2O2 detection with an exceptional limit of detection (LOD) value of 3.5 nM. A mechanism study revealed that two factors, for example, radical scavenging and electroassisted oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) have played significant roles in enhancing detection sensitivity and reducing detection time. BQDs possessed over 80% radical scavenging ability and, under an electrochemical field, demonstrated a 50-fold increase in the oxidation reaction of TMB compared with the conventional method. These remarkable findings were further utilized for the quantification of cholesterol and choline in a simulated blood sample with LOD values of 0.13 and 0.38 μM, respectively. The groundbreaking results presented in this study have the potential to open a pathway to move from the conventional nanozymatic detection method to an electroassisted one in the future.

Original languageEnglish
Pages (from-to)19939-19946
Number of pages8
JournalACS Applied Nano Materials
Volume6
Issue number21
DOIs
StatePublished - 10 Nov 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Funding

The authors would like to acknowledge the support from the Natural Sciences and Engineering Research Council of Canada in the form of Discovery Grants to A.R.R. and S.S. (RGPIN-2019-07246 and RGPIN-2022-04988).

FundersFunder number
Natural Sciences and Engineering Research Council of CanadaRGPIN-2019-07246, RGPIN-2022-04988

    Keywords

    • HO
    • borophene QDs
    • cardiac biomarkers
    • colorimetric
    • nanozyme

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