Borophene Based 3D Extrusion Printed Nanocomposite Hydrogel for Antibacterial and Controlled Release Application

Poushali Das, Sayan Ganguly, Parham Khoshbakht Marvi, Masoomeh Sherazee, Syed Rahin Ahmed, Xiaowu Tang, Seshasai Srinivasan, Amin Reza Rajabzadeh

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Herein, a borophene/zinc oxide (BZ) nanocomposite is synthesized through a straightforward one-step solvothermal process, avoiding the need for any rigorous reducing agent. The BZ nanocomposites are introduced into semi-interpenetrating polymer networks to form hydrogels via in situ UV triggered free radical gelation during three-dimensional (3D) microextrusion printing. The hydrogels exhibit mechanical robustness, high compressibility, pH sensitivity, and microporosity. The diffusion behavior of the hydrogel shows a combination of swelling and molecular chain relaxation based on its water uptake kinetics. Hydrogels are tested in rigorous pH environments over multiple cycles to ensure structural integrity. The rheological assessment of the hydrogels proves their high elasticity. The uniaxial mechanical properties support its mechanical toughness and zero permanent set resulting elastomeric soft matrix. The cyclic compression test up to 100 cycles has negligible data deviations in calculating compression moduli (≈24 kPa). The hydrogels are non-toxic and found to be effective bactericidal materials for both Gram-positive and Gram-negative bacteria. The hydrogel demonstrates pH-responsive time-dependent payload release behavior, suggesting its potential as a soft matrix drug carrier in biomedical research. To the best of the authors knowledge, this is the first report of BZ-based soft biomaterial with antibacterial properties serving as an excellent controlled drug delivery device.

Original languageEnglish
Article number2314520
JournalAdvanced Functional Materials
Volume34
Issue number21
DOIs
StatePublished - 22 May 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.

Funding

The authors would like to acknowledge the support from the Natural Sciences and Engineering Research Council of Canada in the form of Discovery Grants to ARR and SS (RGPIN‐2019‐07246 and RGPIN‐2022‐04988).

FundersFunder number
Natural Sciences and Engineering Research Council of CanadaRGPIN‐2022‐04988, RGPIN‐2019‐07246

    Keywords

    • 2D material
    • 3D printing
    • antibacterial activity
    • borophene
    • drug delivery
    • hydrogel
    • nanocomposite

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