Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Ines Foessl; J. H.Duncan Bassett; Åshild Bjørnerem; Björn Busse; Ângelo Calado; Pascale Chavassieux; Maria Christou; Eleni Douni; Imke A.K. Fiedler; João Eurico Fonseca; Eva Hassler; Wolfgang Högler; Erika Kague; David Karasik; Patricia Khashayar; Bente L. Langdahl; Victoria D. Leitch; Philippe Lopes; Georgios Markozannes; Fiona E.A. McGuigan; Carolina Medina-Gomez; Evangelia Ntzani; Ling Oei; Claes Ohlsson; Pawel Szulc; Jonathan H. Tobias; Katerina Trajanoska; Şansın Tuzun; Amina Valjevac; Bert van Rietbergen; Graham R. Williams; Tatjana Zekic; Fernando Rivadeneira; Barbara Obermayer-Pietsch

doi:10.3389/fendo.2021.720728

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Ines Foessl
, J. H.Duncan Bassett
, Åshild Bjørnerem
, Björn Busse
, Ângelo Calado
, Pascale Chavassieux
, Maria Christou
, Eleni Douni
, Imke A.K. Fiedler
, João Eurico Fonseca
, Eva Hassler
, Wolfgang Högler
, Erika Kague
, David Karasik
, Patricia Khashayar
, Bente L. Langdahl
, Victoria D. Leitch
, Philippe Lopes
, Georgios Markozannes
, Fiona E.A. McGuigan

Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, Barbara Obermayer-Pietsch

Bar-Ilan University - Azrieli Faculty of Medicine

Medical University of Graz
Imperial College London
University of Tromsø – The Arctic University of Norway
University of Oslo
University of Hamburg
University of Lisbon
Université de Lyon
University of Ioannina
Alexander Fleming Biomedical Sciences Research Center
Agricultural University of Athens
Centro Hospitalar Universitário Lisboa Norte
Johannes Kepler University Linz
University of Bristol
Ghent University
Aarhus University
Royal Melbourne Institute of Technology University
Lund University
Erasmus University Rotterdam
Brown University
University of Gothenburg
Sahlgrenska University Hospital
Istanbul University - Cerrahpaşa
University of Sarajevo
Eindhoven University of Technology
University of Rijeka

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

Original language	English
Article number	720728
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.720728
State	Published - 1 Dec 2021

Bibliographical note

Publisher Copyright:
Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.

Funding

Funding was obtained from the GEMSTONE COST Action (CA18139). The Origins of Bone and Cartilage Disease Programme analysed the skeletal phenotypes of knockout mice generated by the International Mouse Phenotyping Consortium (IMPC) and was funded by a Welcome Trust Strategic Award (101123) to GRW and JHDB. IF is enrolled in the PhD program MOLIN at the Medical University of Graz, funded by the Austrian Science Fund (FWF). FM is funded by the Swedish Research Council (2018-02981), Greta and Johan Kock Foundation, the A. Påhlsson, A. Osterlund Foundation and H Järnhardt Foundations, King Gustav V 80 year fund, Swedish Rheumatism foundation, Skåne University Hospital Research Fund, Research and Development Council of Region Skåne.

Funders	Funder number
H Järnhardt Foundations
International Mouse Phenotyping Consortium
Research and Development Council of Region Skåne
Skåne University Hospital Research Fund
Swedish Rheumatism foundation
Wellcome Trust	101123
Austrian Science Fund
Vetenskapsrådet	2018-02981
Greta och Johan Kocks stiftelser
Stiftelsen Konung Gustaf V:s 80-årsfond
Medizinische Universität Graz

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COST
GEMSTONE
animal models
bone and skeletal diseases
imaging
phenotyping

Access to Document

10.3389/fendo.2021.720728

Cite this

Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E., Fiedler, I. A. K., Fonseca, J. E., Hassler, E., Högler, W., Kague, E., Karasik, D., Khashayar, P., Langdahl, B. L., Leitch, V. D., Lopes, P., Markozannes, G., ... Obermayer-Pietsch, B. (2021). Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). Frontiers in Endocrinology, 12, Article 720728. https://doi.org/10.3389/fendo.2021.720728

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abstract = "A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.",

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author = "Ines Foessl and Bassett, \{J. H.Duncan\} and {\AA}shild Bj{\o}rnerem and Bj{\"o}rn Busse and {\^A}ngelo Calado and Pascale Chavassieux and Maria Christou and Eleni Douni and Fiedler, \{Imke A.K.\} and Fonseca, \{Jo{\~a}o Eurico\} and Eva Hassler and Wolfgang H{\"o}gler and Erika Kague and David Karasik and Patricia Khashayar and Langdahl, \{Bente L.\} and Leitch, \{Victoria D.\} and Philippe Lopes and Georgios Markozannes and McGuigan, \{Fiona E.A.\} and Carolina Medina-Gomez and Evangelia Ntzani and Ling Oei and Claes Ohlsson and Pawel Szulc and Tobias, \{Jonathan H.\} and Katerina Trajanoska and {\c S}ansın Tuzun and Amina Valjevac and \{van Rietbergen\}, Bert and Williams, \{Graham R.\} and Tatjana Zekic and Fernando Rivadeneira and Barbara Obermayer-Pietsch",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Foessl, Bassett, Bj{\o}rnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, H{\"o}gler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.",

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doi = "10.3389/fendo.2021.720728",

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Foessl, I, Bassett, JHD, Bjørnerem, Å, Busse, B, Calado, Â, Chavassieux, P, Christou, M, Douni, E, Fiedler, IAK, Fonseca, JE, Hassler, E, Högler, W, Kague, E, Karasik, D, Khashayar, P, Langdahl, BL, Leitch, VD, Lopes, P, Markozannes, G, McGuigan, FEA, Medina-Gomez, C, Ntzani, E, Oei, L, Ohlsson, C, Szulc, P, Tobias, JH, Trajanoska, K, Tuzun, Ş, Valjevac, A, van Rietbergen, B, Williams, GR, Zekic, T, Rivadeneira, F & Obermayer-Pietsch, B 2021, 'Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)', Frontiers in Endocrinology, vol. 12, 720728. https://doi.org/10.3389/fendo.2021.720728

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). / Foessl, Ines; Bassett, J. H.Duncan; Bjørnerem, Åshild et al.
In: Frontiers in Endocrinology, Vol. 12, 720728, 01.12.2021.

Research output: Contribution to journal › Review article › peer-review

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AU - Foessl, Ines

AU - Bassett, J. H.Duncan

AU - Bjørnerem, Åshild

AU - Busse, Björn

AU - Calado, Ângelo

AU - Chavassieux, Pascale

AU - Christou, Maria

AU - Douni, Eleni

AU - Fiedler, Imke A.K.

AU - Fonseca, João Eurico

AU - Hassler, Eva

AU - Högler, Wolfgang

AU - Kague, Erika

AU - Karasik, David

AU - Khashayar, Patricia

AU - Langdahl, Bente L.

AU - Leitch, Victoria D.

AU - Lopes, Philippe

AU - Markozannes, Georgios

AU - McGuigan, Fiona E.A.

AU - Medina-Gomez, Carolina

AU - Ntzani, Evangelia

AU - Oei, Ling

AU - Ohlsson, Claes

AU - Szulc, Pawel

AU - Tobias, Jonathan H.

AU - Trajanoska, Katerina

AU - Tuzun, Şansın

AU - Valjevac, Amina

AU - van Rietbergen, Bert

AU - Williams, Graham R.

AU - Zekic, Tatjana

AU - Rivadeneira, Fernando

AU - Obermayer-Pietsch, Barbara

N1 - Publisher Copyright: Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.

PY - 2021/12/1

Y1 - 2021/12/1

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AB - A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

KW - COST

KW - GEMSTONE

KW - animal models

KW - bone and skeletal diseases

KW - imaging

KW - phenotyping

UR - https://www.scopus.com/pages/publications/85121349738

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SN - 1664-2392

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JO - Frontiers in Endocrinology

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M1 - 720728

ER -

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this