Bone marrow regeneration under cytotoxic drug regimens: behaviour ranging from homeostasis to unpredictability in a model for hemopoietic differentiation

Ramit Mehr, Zvia Agur

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In the process of hemopoiesis, bone marrow stem cells differentiate into the various types of mature blood cells. We present a model for bone marrow dynamics, which retrieves its ability to continuously modulate the balance between self-renewal and differentiation, even under periodic cytodestructive perturbations. Yet, a temporally stochastic perturbation results in chaoticlike behaviour which has no deterministic source.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalBioSystems
Volume26
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Bibliographical note

Funding Information:
We are much obliged to I. Procaccia and to D. Zipori for very helpful discussions. The work was supported by the John D. and Catherine T. MacArthur Foundation and by the Israeli Health Ministry.

Keywords

  • Cellular automata
  • Chaos
  • Colony-forming units
  • Nonlinear dynamics
  • Stem cells

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