Bone marrow regeneration under cytotoxic drug regimens: behaviour ranging from homeostasis to unpredictability in a model for hemopoietic differentiation

Ramit Mehr; Zvia Agur

doi:10.1016/0303-2647(92)90028-w

Bone marrow regeneration under cytotoxic drug regimens: behaviour ranging from homeostasis to unpredictability in a model for hemopoietic differentiation

Ramit Mehr, Zvia Agur

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

In the process of hemopoiesis, bone marrow stem cells differentiate into the various types of mature blood cells. We present a model for bone marrow dynamics, which retrieves its ability to continuously modulate the balance between self-renewal and differentiation, even under periodic cytodestructive perturbations. Yet, a temporally stochastic perturbation results in chaoticlike behaviour which has no deterministic source.

Original language	English
Pages (from-to)	231-237
Number of pages	7
Journal	BioSystems
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/0303-2647(92)90028-w
State	Published - 1992
Externally published	Yes

Bibliographical note

Funding Information:
We are much obliged to I. Procaccia and to D. Zipori for very helpful discussions. The work was supported by the John D. and Catherine T. MacArthur Foundation and by the Israeli Health Ministry.

Funding

We are much obliged to I. Procaccia and to D. Zipori for very helpful discussions. The work was supported by the John D. and Catherine T. MacArthur Foundation and by the Israeli Health Ministry.

Funders	Funder number
Israeli Health Ministry
John D. and Catherine T. MacArthur Foundation

Keywords

Cellular automata
Chaos
Colony-forming units
Nonlinear dynamics
Stem cells

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10.1016/0303-2647(92)90028-w

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abstract = "In the process of hemopoiesis, bone marrow stem cells differentiate into the various types of mature blood cells. We present a model for bone marrow dynamics, which retrieves its ability to continuously modulate the balance between self-renewal and differentiation, even under periodic cytodestructive perturbations. Yet, a temporally stochastic perturbation results in chaoticlike behaviour which has no deterministic source.",

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Bone marrow regeneration under cytotoxic drug regimens: behaviour ranging from homeostasis to unpredictability in a model for hemopoietic differentiation

Abstract

Bibliographical note

Funding

Keywords

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