Body mass index at age 18 years and during adult life and ovarian cancer risk

F. Lubin; A. Chetrit; L. S. Freedman; E. Alfandary; Y. Fishier; H. Nitzan; A. Zultan; B. Modan

doi:10.1093/aje/kwf184

Body mass index at age 18 years and during adult life and ovarian cancer risk

F. Lubin, A. Chetrit, L. S. Freedman, E. Alfandary, Y. Fishier, H. Nitzan, A. Zultan, B. Modan

Department of Mathematics

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

During the years 1994-1999, a nationwide ovarian cancer case-control study was conducted in Israel. The present analysis addresses the question: Is epithelial ovarian cancer associated with body mass index at age 18 years and/or with weight changes in body mass index between adolescence and adult life? The study is based on 1,269 women with epithelial ovarian cancer and 2,111 matched controls. A significant decrease in risk of ovarian cancer was observed with parity, oral contraceptive use, and postmenopausal status. A significant increase in risk with family history of ovarian/breast cancer was also found. No significant association with age at menarche or infertility was found. For body mass index at age 18 years, the odds ratio of the highest versus lowest body mass index quartile was 1.42 (95% confidence interval: 1.08, 1.85) and after adjusting for confounders was 1.54 (95% confidence interval: 1.17, 2.02). However, no statistically significant risk associated with change in weight from age 18 years to adult life was found. The authors conclude that, in their population, body mass index at age 18 years is an independent risk factor for ovarian cancer.

Original language	English
Pages (from-to)	113-120
Number of pages	8
Journal	American Journal of Epidemiology
Volume	157
Issue number	2
DOIs	https://doi.org/10.1093/aje/kwf184
State	Published - 15 Jan 2003

Bibliographical note

Funding Information:
Supported in part by a research grant from the National Cancer Institute, Bethesda, Maryland (R01-CA61126-01-03), and by contracts with Westat, Rockville, Maryland (NO2-CP-60534 and NO2-CP-91026), and Information Management Services, Silver Spring, Maryland (MS NO2-CP-81005).

Funding

Supported in part by a research grant from the National Cancer Institute, Bethesda, Maryland (R01-CA61126-01-03), and by contracts with Westat, Rockville, Maryland (NO2-CP-60534 and NO2-CP-91026), and Information Management Services, Silver Spring, Maryland (MS NO2-CP-81005).

Funders	Funder number
National Cancer Institute	MS NO2-CP-81005, NO2-CP-91026, NO2-CP-60534, R01CA061126, R01-CA61126-01-03

Keywords

Body mass index
Ovarian neoplasms
Risk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/aje/kwf184

Cite this

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abstract = "During the years 1994-1999, a nationwide ovarian cancer case-control study was conducted in Israel. The present analysis addresses the question: Is epithelial ovarian cancer associated with body mass index at age 18 years and/or with weight changes in body mass index between adolescence and adult life? The study is based on 1,269 women with epithelial ovarian cancer and 2,111 matched controls. A significant decrease in risk of ovarian cancer was observed with parity, oral contraceptive use, and postmenopausal status. A significant increase in risk with family history of ovarian/breast cancer was also found. No significant association with age at menarche or infertility was found. For body mass index at age 18 years, the odds ratio of the highest versus lowest body mass index quartile was 1.42 (95% confidence interval: 1.08, 1.85) and after adjusting for confounders was 1.54 (95% confidence interval: 1.17, 2.02). However, no statistically significant risk associated with change in weight from age 18 years to adult life was found. The authors conclude that, in their population, body mass index at age 18 years is an independent risk factor for ovarian cancer.",

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Body mass index at age 18 years and during adult life and ovarian cancer risk

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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