Biopolymer stereocomplexes

Joram Slager, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

256 Scopus citations

Abstract

A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on stereoselective van der Waals forces. This review focuses mainly on homo-stereocomplexes of poly(methyl methacrylate) homo- and block-copolymers, which are non-degradable biopolymers, and biodegradable poly(lactic acid) (PLA) homo- and block-copolymers and hetero-stereocomplexes between D-configured PLA and L-configured peptides. Topics including physical methods for characterization and visualization and the use as matrices for controlled release, tissue engineering or other biomedical purposes, are discussed for the different stereocomplexes.

Original languageEnglish
Pages (from-to)549-583
Number of pages35
JournalAdvanced Drug Delivery Reviews
Volume55
Issue number4
DOIs
StatePublished - 25 Apr 2003
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from the Israeli Science Foundation (ISF), the Alex Grass Center for Drug Design and Synthesis, the David R. Bloom Center for Pharmaceutical Science and a grant from PolyGene.

Keywords

  • Biodegradable polymers
  • Hetero-complexes
  • Peptide delivery
  • Peptide interactions
  • Poly(lactic acid)
  • Poly(methyl methacrylate)
  • Polymeric diastereomers
  • Stereocomplex

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