Abstract
A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on stereoselective van der Waals forces. This review focuses mainly on homo-stereocomplexes of poly(methyl methacrylate) homo- and block-copolymers, which are non-degradable biopolymers, and biodegradable poly(lactic acid) (PLA) homo- and block-copolymers and hetero-stereocomplexes between D-configured PLA and L-configured peptides. Topics including physical methods for characterization and visualization and the use as matrices for controlled release, tissue engineering or other biomedical purposes, are discussed for the different stereocomplexes.
| Original language | English |
|---|---|
| Pages (from-to) | 549-583 |
| Number of pages | 35 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 55 |
| Issue number | 4 |
| DOIs | |
| State | Published - 25 Apr 2003 |
| Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by grants from the Israeli Science Foundation (ISF), the Alex Grass Center for Drug Design and Synthesis, the David R. Bloom Center for Pharmaceutical Science and a grant from PolyGene.
Funding
This work was supported by grants from the Israeli Science Foundation (ISF), the Alex Grass Center for Drug Design and Synthesis, the David R. Bloom Center for Pharmaceutical Science and a grant from PolyGene.
| Funders | Funder number |
|---|---|
| Israeli Science Foundation | |
| PolyGene |
Keywords
- Biodegradable polymers
- Hetero-complexes
- Peptide delivery
- Peptide interactions
- Poly(lactic acid)
- Poly(methyl methacrylate)
- Polymeric diastereomers
- Stereocomplex