Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

M. Satyanarayana; K. Yugender Goud; K. Koteshwara Reddy; K. Vengatajalabathy Gobi

doi:10.1016/j.electacta.2015.08.036

Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

M. Satyanarayana
, K. Yugender Goud
, K. Koteshwara Reddy
, K. Vengatajalabathy Gobi

National Institute of Technology Warangal

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.

Original language	English
Article number	25504
Pages (from-to)	608-616
Number of pages	9
Journal	Electrochimica Acta
Volume	178
DOIs	https://doi.org/10.1016/j.electacta.2015.08.036
State	Published - 1 Oct 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Funding

The authors gratefully acknowledge the Ministry of Human Resource Development, India and the National Institute of Technology, Warangal for Junior Research Fellowship to MS and for financial support.

Funders
National Institute of Technology
Ministry of Human Resource Development

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

5-Fluorouracil
Carbon nanotubes
Chitosan
Electrocatalysis
Gold Nanoparticles
Voltammetric determination

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10.1016/j.electacta.2015.08.036

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title = "Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro",

abstract = "A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.",

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author = "M. Satyanarayana and Goud, \{K. Yugender\} and Reddy, \{K. Koteshwara\} and Gobi, \{K. Vengatajalabathy\}",

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AU - Satyanarayana, M.

AU - Goud, K. Yugender

AU - Reddy, K. Koteshwara

AU - Gobi, K. Vengatajalabathy

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AB - A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.

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KW - Carbon nanotubes

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KW - Electrocatalysis

KW - Gold Nanoparticles

KW - Voltammetric determination

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Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

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