Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

M. Satyanarayana; K. Yugender Goud; K. Koteshwara Reddy; K. Vengatajalabathy Gobi

doi:10.1016/j.electacta.2015.08.036

Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

M. Satyanarayana, K. Yugender Goud, K. Koteshwara Reddy, K. Vengatajalabathy Gobi

Research output: Contribution to journal › Article › peer-review

Abstract

A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.

Original language	English
Article number	25504
Pages (from-to)	608-616
Number of pages	9
Journal	Electrochimica Acta
Volume	178
DOIs	https://doi.org/10.1016/j.electacta.2015.08.036
State	Published - 1 Oct 2015
Externally published	Yes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the Ministry of Human Resource Development, India and the National Institute of Technology, Warangal for Junior Research Fellowship to MS and for financial support.

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

5-Fluorouracil
Carbon nanotubes
Chitosan
Electrocatalysis
Gold Nanoparticles
Voltammetric determination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.electacta.2015.08.036

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title = "Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro",

abstract = "A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.",

keywords = "5-Fluorouracil, Carbon nanotubes, Chitosan, Electrocatalysis, Gold Nanoparticles, Voltammetric determination",

author = "M. Satyanarayana and Goud, {K. Yugender} and Reddy, {K. Koteshwara} and Gobi, {K. Vengatajalabathy}",

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AU - Reddy, K. Koteshwara

AU - Gobi, K. Vengatajalabathy

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AB - A fast and facile electrochemical sensor for the detection of an important anti-cancer drug, 5-fluorouracil, is fabricated using a gold nanoparticle decorated multiwall carbon nanotube (GNP-MWCNT) composite modified electrode. GNP-MWCNT composite has been prepared by a simple one-pot synthesis in the presence of chitosan, which acts as a reducing as well as stabilizing agent. Synthesized GNP-MWCNT is characterized by UV-Visible spectroscopy, Raman spectroscopy, XRD analysis and FESEM for the structural and chemical properties of nanocomposite, and the size of the gold nanoparticles is determined to be ∼30 nm by different methods. The electrochemical capability of the fabricated GNP-MWCNT composite modified electrode for the detection of 5-FU is examined by cyclic voltammetry, electrochemical impedance analysis and differential pulse voltammetry. The nanoAu decorated carbon nanotube electrode is found to be efficient for electrocatalytic oxidation of 5-FU. Peak current of the DPVs exhibited a linear relationship against 5-FU over a wide concentration range of 0.03-10 μM with a low-detection-limit (3σ/b) of 20 nM, and the analysis time is as low as 25 s. Practical utility of the developed GNP-MWCNT nanocomposite biosensor has been demonstrated for the detection of 5-FU directly from artificial urine and pharmaceutical formulations with good recovery limits.

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Biopolymer Stabilized Nanogold Particles on Carbon Nanotube Support as Sensing Platform for Electrochemical Detection of 5-Fluorouracil in-vitro

Abstract

Bibliographical note

Keywords

UN SDGs

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