Biomarkers for CNS involvement in pediatric lupus

Tamar B. Rubinstein, Chaim Putterman, Beatrice Goilav

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population.

Original languageEnglish
Pages (from-to)545-558
Number of pages14
JournalBiomarkers in Medicine
Issue number6
StatePublished - 1 Jun 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Future Medicine Ltd.


  • CNS
  • biomarkers
  • neuropsychiatric
  • pediatric
  • systemic lupus erythematosus


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