Biological applications of optical tags based on surface-enhanced Raman scattering

William E. Doering, Michael Y. Sha, David Guagliardo, Glenn Davis, Remy Cromer, Michael J. Natan, R. Griffith Freeman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Detection tags are needed in biological assays to identify specific products or events from among the thousands of molecules and events present in a cell or biological extract. Although there are measurement techniques that can directly detect a wide variety of native molecules (including mass spectrometry and nuclear magnetic resonance [NMR]), in complex biological systems, it is often useful to tag a specific molecule of interest to make it “visible” to a detection system. Optical tagging techniques are often favored because they can be applied to virtually any measurement format, from microarrays to cellular assays to in vivo applications.

Original languageEnglish
Title of host publicationBionanotechnology
Subtitle of host publicationGlobal Prospects
PublisherCRC Press
Number of pages15
ISBN (Electronic)9781420007732
ISBN (Print)9780849375286
StatePublished - 1 Jan 2008
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2009 by Taylor & Francis Group, LLC.


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