Biolabile peptidyl delivery systems toward sequential drug release

Elena Ragozin, Boris Redko, Elena Tuchinsky, Alex Rozovsky, Amnon Albeck, Flavio Grynszpan, Gary Gellerman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Compact carriers for peptidyl delivery systems (PDSs) loaded with various drugs were synthesized using a simple and convenient solid phase organic synthesis strategy, including semi-orthogonal functional group protection schemes. Each attachment point of the compact carrier can thus be bound to an anticancer agent through a biodegradable covalent link. Chemo- and biostability experiments of a model peptidyl platform loaded with three different drugs revealed pH and liver homogenate (metabolic) dependent sequential release behavior. The versatility of this approach will serve to expedite the preparation of PDS libraries. This approach may prove useful for applications suitable for personalized medicine where multiple drug delivery is required in a sequential and controlled fashion.

Original languageEnglish
Pages (from-to)119-132
Number of pages14
Issue number1
StatePublished - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© 2015 Wiley Periodicals, Inc.


  • biostability
  • chemostability
  • drug delivery
  • multiple drug delivery
  • peptidyl delivery system
  • prodrug
  • sequential drug release


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