Abstract
Small interfering RNAs (siRNAs) technology has shown great promise as a new class of therapeutics invention for treatment of cancer and other diseases. siRNA has been used extensively in blocking various genes and is presently being evaluated as a therapeutic for cancer and viral disease. Despite the excitement about this remarkable biological process for sequence specific gene regulation, the major limitations against the use of siRNAs-based therapeutics are their rapid degradation by serum nuclease, poor cellular uptake, and rapid renal clearance following systemic delivery, off-target effects, and induction of immune responses. Many researchers have tried to overcome these limitations with developing nuclease-resistant chemically modified siRNAs and variety of synthetic and natural biodegradable lipids and polymers for siRNA delivery to enhance efficacy and safety profiles. An ideal siRNAs-based delivery system must be clinically suitable, safe, and effective. This review discuss the recent progress of biodegradable polymers in siRNA delivery technology.
| Original language | English |
|---|---|
| Pages (from-to) | 2647-2655 |
| Number of pages | 9 |
| Journal | Polymers for Advanced Technologies |
| Volume | 30 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1 Oct 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 John Wiley & Sons, Ltd.
Keywords
- biodegradable poylmers
- drug delivery
- nanoparticles
- nonviral vectors
- siRNA
