Biodegradable polymers in gene-silencing technology

Hossein Hosseinkhani, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Small interfering RNAs (siRNAs) technology has shown great promise as a new class of therapeutics invention for treatment of cancer and other diseases. siRNA has been used extensively in blocking various genes and is presently being evaluated as a therapeutic for cancer and viral disease. Despite the excitement about this remarkable biological process for sequence specific gene regulation, the major limitations against the use of siRNAs-based therapeutics are their rapid degradation by serum nuclease, poor cellular uptake, and rapid renal clearance following systemic delivery, off-target effects, and induction of immune responses. Many researchers have tried to overcome these limitations with developing nuclease-resistant chemically modified siRNAs and variety of synthetic and natural biodegradable lipids and polymers for siRNA delivery to enhance efficacy and safety profiles. An ideal siRNAs-based delivery system must be clinically suitable, safe, and effective. This review discuss the recent progress of biodegradable polymers in siRNA delivery technology.

Original languageEnglish
Pages (from-to)2647-2655
Number of pages9
JournalPolymers for Advanced Technologies
Volume30
Issue number10
DOIs
StatePublished - 1 Oct 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.

Keywords

  • biodegradable poylmers
  • drug delivery
  • nanoparticles
  • nonviral vectors
  • siRNA

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