Biodegradable polymers derived from amino acids

Wahid Khan, Saravanan Muthupandian, Shady Farah, Neeraj Kumar, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.

Original languageEnglish
Pages (from-to)1625-1636
Number of pages12
JournalMacromolecular Bioscience
Volume11
Issue number12
DOIs
StatePublished - 8 Dec 2011
Externally publishedYes

Keywords

  • Amino acids
  • Biocompatibility
  • Biodegradable polymers
  • Biomaterials
  • Functional polymers

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