Biodegradable Poly(Acetonide Gluconic Acid) for Controlled Drug Delivery

Ester Abtew, Aviva F. Ezra, Arijit Basu, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We report here on the synthesis, characterization, degradation, and drug release of acetal-protected gluconic acid-based poly(α-hydroxy ester). This polyester was synthesized by ring-opening polymerization of O-carboxyanhydride of acetal-protected gluconic acid. The polymer undergoes hydrolytic degradation under mild acidic media, whereas minimal degradation takes place under physiological pH. Under acidic conditions, the acetal-protecting groups are hydrolyzed, resulting in a water-soluble polyester with saccharide side chains that erodes from the surface, leaving the bulk of the polymer matrix intact. At pH 3.5, zero-order kinetics was maintained for 50 days accounting for ∼75% drug release. These biodegradable, pH-responsive, sustained zero-order release kinetics of the polymer have application as drug carriers for oral drug delivery or medical implants or also for nonmedical applications.

Original languageEnglish
Pages (from-to)2934-2941
Number of pages8
JournalBiomacromolecules
Volume20
Issue number8
DOIs
StatePublished - 12 Aug 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

Funding

The research is supported by Israeli Science Foundation Research Grant no. 235/17.

FundersFunder number
Israeli Science Foundation235/17

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