Biodegradable Hydrophobic Injectable Polymers for Drug Delivery and Regenerative Medicine

Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Biodegradable, hydrophobic, and injectable liquid polymers are capable of achieving the minimally invasive, sustained, and local release of drugs. These hydrophobic injectable polymers also have potential in the area of regenerative medicine where the biomaterial should be stable for a certain period and then degrade to allow the growth of cells/tissues. This review presents exclusive coverage of biocompatible hydrophobic injectable pasty or liquid polymers that can be injected without the use of any solvent for drug delivery, tissue augmentation, and regenerative medicine application. The synthesis methodologies of several major types of hydrophobic pasty polymers used in the biomedical fields and their properties with the foremost criteria to serve as injectable biomaterial for localized drug delivery and regenerative medicine is described. The hydrophobic biodegradable injectable polymers discussed are aliphatic polyesters, polycarbonates and polyanhydrides, prepared from: lactic acid, glycolic acid, caprolactone, aliphatic diols and diacids, hydroxy fatty acids, and triglycerides such as castor oil.

Original languageEnglish
Article number2010284
JournalAdvanced Functional Materials
Volume31
Issue number44
DOIs
StatePublished - 26 Oct 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

  • biomaterials
  • drug delivery
  • hydrophobic polymers
  • injectable polymers
  • regenerative medicine

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