Biocompatible N-doped carbon dots for the eradication of methicillin-resistant S. aureus (MRSA) and sensitive analysis for europium (III)

Moorthy Maruthapandi, Poushali Das, Arumugam Saravanan, Michal Natan, Ehud Banin, Sriram Kannan, Shulamit Michaeli, John H.T. Luong, Aharon Gedanken

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Plant leaves have more attracted in the preparation of carbon dots (CDs) owing to natural phytochemicals. Herein, we performed a one-pot hydrothermal process for the synthesis of Nitrogen doped CDs (N@CDs) from glossy heart-shaped Piper betel leaves (P. betel). The prepared N@CDs were effectively applied for the eradication of E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA). The N@CDs were also used as a sensor for lanthanides detection with notable selectivity for Eu3+. The results revealed that the water-soluble N@CDs displayed narrow size particle distribution with a mean diameter of 2.6 nm. The bright fluorescence was estimated to be at λex: 350 with λem: 430 nm. The functional groups on N@CDs were confirmed by FTIR and XPS. The antimicrobial effect of N@CDs was concentration-dependent and effectively against E. coli and S. aureus at 1000 μg/mL. The antibacterial results reveal that the N@CDs exhibit the selective and superior killing effect against antibiotic-resistant bacteria (MRSA). The biocompatibility of CDs explored using THP- 1 monocytes cells. The N@CDs were also applicable for sensitive and selective detection of Eu3+ with LOD of 68 μM over other lanthanides in an aqueous solution by fluorescence quenching.

Original languageEnglish
Article number100724
JournalNano-Structures and Nano-Objects
Volume26
DOIs
StatePublished - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Antibacterial activity
  • Betel leaves
  • Cytotoxicity
  • Eu detection
  • Green synthesis
  • N@CDs

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