Biocompatibility of a polymeric implant for the treatment of osteomyelitis

Y. S. Brin, A. Nyska, A. J. Domb, J. Golenser, B. Mizrahi, M. Nyska

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We evaluated the biocompatibility of an injectable gelling polymeric device for the controlled release of gentamicin sulfate in the treatment of invasive bacterial infections in bone of male Wister rats. The biodegradable delivery carrier, poly(sebacic-co-ricinoleic-ester-anhydride), designated as p(SA:RA), was injected, with and without gentamicin, into the tibial canal. Rats were killed 3 weeks later. The tibiae were processed histologically, leaving the injectable polymer in situ. The local tissue reaction to the polymer with or without antibiotic consisted mainly of mild reactive fibroplasia/fibrosis and mild to moderate increased reactive bone formation. At this stage, no evidence for any active inflammatory response to the polymer was seen. Thus, the injection of p(SA:RA) was well tolerated and did not induce any signs of a progressive inflammatory reaction.

Original languageEnglish
Pages (from-to)1081-1090
Number of pages10
JournalJournal of Biomaterials Science, Polymer Edition
Issue number7-8
StatePublished - 1 Apr 2009
Externally publishedYes


  • Biocompatible degradable polymer
  • Controlled delivery
  • Gentamicin
  • Tibial implant
  • Toxicity evaluation


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