Biocompatibility and safety of PLA and its copolymers

Yuval Ramot, Moran Haim-Zada, Abraham J. Domb, Abraham Nyska

Research output: Contribution to journalReview articlepeer-review

412 Scopus citations


PLA and its copolymers are commonly used for a wide variety of applications. While they are considered to be biocompatible, side effects resulting from their implantation have been reported. The implantation of biomaterials always results in a foreign body reaction. Such a reaction has also been reported following PLA and its copolymers. This article reviews the process of inflammatory reaction that is to be expected following implantation of PLA, and it highlights specific cases in which the inflammatory reaction can result in safety concerns. The authors also review selected cases from different medical fields to demonstrate possible clinical side effects resulting from its use.

Original languageEnglish
Pages (from-to)153-162
Number of pages10
JournalAdvanced Drug Delivery Reviews
StatePublished - 15 Dec 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.


  • Biocompatibility
  • Degradable materials
  • PLA
  • PLGL
  • Polymers
  • Toxicity


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