Bioactive acetylenic metabolites

Dmitry V. Kuklev, Abraham J. Domb, Valery M. Dembitsky

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

This article focuses on anticancer, and other biological activities of acetylenic metabolites obtained from plants and fungi. Acetylenic compounds belong to a class of molecules containing triple bond(s). Naturally occurring acetylenics are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. There are of great interest for medicine, pharmacology, medicinal chemistry, and pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 100 acetylenic metabolites, including fatty alcohols, ketones, and acids, acetylenic cyclohexanoids, spiroketal enol ethers, and carotenoids isolated from fungi and plants.

Original languageEnglish
Pages (from-to)1145-1159
Number of pages15
JournalPhytomedicine
Volume20
Issue number13
DOIs
StatePublished - 15 Oct 2013
Externally publishedYes

Keywords

  • Acetylenic metabolits
  • Acids
  • Antibacterial Fatty alcohols
  • Antifungal
  • Antitumor
  • Carotenoids
  • Cyclohexanoids
  • Fungi
  • Plants
  • Polyacetylenes
  • Polyynes

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