Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia

I. Hakim; N. Amariglio; F. Brok-Simoni; Z. Grossman; B. Ramot; I. Ben-Bassat; G. Rechavi

Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia

I. Hakim
, N. Amariglio
, F. Brok-Simoni
, Z. Grossman
, B. Ramot
, I. Ben-Bassat
, G. Rechavi

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The distribution of three immunoglobulin heavy chain variable region gene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.

Original language	English
Pages (from-to)	7-9
Number of pages	3
Journal	Israel Journal of Medical Sciences
Volume	30
Issue number	1
State	Published - Jan 1994
Externally published	Yes

Keywords

Chronic lymphocytic leukemia
Immunoglobulin genes
Polymerase chain reaction

Cite this

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title = "Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia",

abstract = "The distribution of three immunoglobulin heavy chain variable region gene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.",

keywords = "Chronic lymphocytic leukemia, Immunoglobulin genes, Polymerase chain reaction",

author = "I. Hakim and N. Amariglio and F. Brok-Simoni and Z. Grossman and B. Ramot and I. Ben-Bassat and G. Rechavi",

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AU - Hakim, I.

AU - Amariglio, N.

AU - Brok-Simoni, F.

AU - Grossman, Z.

AU - Ramot, B.

AU - Ben-Bassat, I.

AU - Rechavi, G.

PY - 1994/1

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AB - The distribution of three immunoglobulin heavy chain variable region gene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.

KW - Chronic lymphocytic leukemia

KW - Immunoglobulin genes

KW - Polymerase chain reaction

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Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia

Abstract

Keywords

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