TY - JOUR
T1 - Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia
AU - Hakim, I.
AU - Amariglio, N.
AU - Brok-Simoni, F.
AU - Grossman, Z.
AU - Ramot, B.
AU - Ben-Bassat, I.
AU - Rechavi, G.
PY - 1994/1
Y1 - 1994/1
N2 - The distribution of three immunoglobulin heavy chain variable region gene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.
AB - The distribution of three immunoglobulin heavy chain variable region gene subgroups (V(H)1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the V(H)5 subgroup was observed relative to its small size.
KW - Chronic lymphocytic leukemia
KW - Immunoglobulin genes
KW - Polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=0028128066&partnerID=8YFLogxK
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C2 - 7511135
AN - SCOPUS:0028128066
SN - 0021-2180
VL - 30
SP - 7
EP - 9
JO - Israel Journal of Medical Sciences
JF - Israel Journal of Medical Sciences
IS - 1
ER -