Behavioral effects of gut hormones in neonatal rats: II. Cholecystokinin administration during the first postnatal week

Aron Weller, Aviram Rozin

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5 Scopus citations


This exploratory study attempted to uncover physical and behavioral consequences of changes in the peripheral cholecystokinin (CCK) system in the first postnatal week. Sprague-Dawley rat pups received s.c. injections of CCK (8 μg/kg) or saline. on postnatal days 1-7 (2 times/day). Physical growth and neurobehavioral development of the pups were assessed on days 3, 6, 9 & 12, their social play was assessed on day 35, and the maternal behavior of their dams was assessed on days 9-12. CCK administration was associated with slower maturation of physical characteristics, more rapid reflexive performance on day 9, and increased maternal licking of pups. These findings stress the importance of further examining the impact of CCK and other gut-hormones an physical and behavioral development and on the quality of the mother-infant interaction

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalInternational Journal of Neuroscience
Issue number1-4
StatePublished - 1993

Bibliographical note

Funding Information:
Please address all correspondence to: Dr. Aron Weller, Department of Psychology, Bar Ilan University, Ramat Can, Israel. Bitnet: F41410 @ BAKILVM. FAX: 972-3-5351825. Work in the Developmental Psychobiology laboratory is supported by the Charles E. Smith Family Foundation-the National Institute for Psychobiology in Israel; The Yigal Alon Fund; and a Bar-llan University internal research fund, all to A. W. The authors express their gratitude to Prof. Shlomo Yehuda for critical review of the manuscript and to Mor Segal, Limor Chen, Eli Yarden, Ofira Shor, Sant Nirel & Sagit Hanf for help in the research.


  • Cholecystokinin octapeptide (CCK-8)
  • Gut-hormones
  • Maternal behavior
  • Neonatal rats
  • Neurobehavioral development
  • Social play


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