Basal splicing factors regulate the stability of mature mRNAs in trypanosomes

Sachin Kumar Gupta, Shai Carmi, Hiba Waldman Ben-Asher, Itai Dov Tkacz, Ilana Naboishchikov, Shulamit Michaeli

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Background: Trypanosome trans-splicing depends on basal splicing factors such as U2AF35, U2FA65, and SF1. Results: Transcriptome analyses of RNAi-silenced cells of basal splicing factors reveal differential reliance on factors for trans-splicing and a role for the splicing factors in mRNA stability. Conclusion: Basal splicing factors regulate trans-splicing and mRNA stability. Significance: This is the first study to suggest that basal splicing factors regulate mRNA stability.

Original languageEnglish
Pages (from-to)4991-5006
Number of pages16
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - 15 Feb 2013

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