BAG-1 is preferentially expressed in neuronal precursor cells of the adult mouse brain and regulates their proliferation in vitro

Evan Elliott; Irith Ginzburg

doi:10.1016/j.febslet.2008.12.009

BAG-1 is preferentially expressed in neuronal precursor cells of the adult mouse brain and regulates their proliferation in vitro

Evan Elliott, Irith Ginzburg

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BAG-1 protein has been well characterized as necessary for proper neuronal development. However, little is known about the function of BAG-1 in the adult brain. In this work, the expression and localization of BAG-1 in the mature mouse brain was studied. The levels of both BAG-1 isoforms decrease significantly in the brain during development. BAG-1 was found preferentially expressed in Neuronal Precursor Cells (NPCs) in the two major niches of neurogenesis. Lentiviral mediated overexpression of BAG-1 increased the proliferation rate of cultured NPCs. In addition, depletion of BAG-1 from NPCs induced a decrease in NPCs proliferation in the presence of a stress hormone, corticosterone. These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	FEBS Letters
Volume	583
Issue number	1
DOIs	https://doi.org/10.1016/j.febslet.2008.12.009
State	Published - 5 Jan 2009
Externally published	Yes

Keywords

BAG-1
Neurogenesis
Neuronal precursor cell
Proliferation

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10.1016/j.febslet.2008.12.009

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BAG-1 is preferentially expressed in neuronal precursor cells of the adult mouse brain and regulates their proliferation in vitro

Abstract

Keywords

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