B-cell biology

Elena Weinstein, Elena Peeva, Chaim Putterman, Betty Diamond

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


B-lymphocyte functions can be divided broadly into antigen presentation and production of antibodies. Defects in either of these functions may lead to immunodeficiency or autoimmunity. For the rheumatologist, it is important to understand B-cell development, maturation, and activation to fully comprehend how alterations in these processes shape the B-cell repertoire and can lead eventually to autoimmunity and organ pathology. The goal of this article is to demonstrate how small changes in the selection of the B-cell repertoire, can, over time, and with the necessary environmental influences, lead to rheumatic disease.

Original languageEnglish
Pages (from-to)159-174
Number of pages16
JournalRheumatic Disease Clinics of North America
Issue number1
StatePublished - Feb 2004
Externally publishedYes


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