Autoradiographic localization of strychnine-sensitive glycine receptor in bovine adrenal medulla

G. Yadid, G. Maor, M. B.H. Youdim, M. Silberman, O. Zinder

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The presence of an uptake system and a functional glycine receptor in adrenal medulla chromaffin cells was investigated using an autoradiographic technique in adrenal gland slices. Specific3[H]-glycine binding was observed in both adrenal cortex and medulla slices, while only specific binding of [3H]strychnine was seen only in chromaffin cells and was not associated with cortical cells. [3H]Glycine binding sites in the cortex are apparently different from those of [3H]strychnine binding sites in the medulla since excess strychnine does not displace [3H]glycine from adrenal cortex but does so from medulla. This difference supports biochemical evidence for glycine transport into medulla cells and glycine receptor sites on the chromaffin cell membrane.

Original languageEnglish
Pages (from-to)1051-1055
Number of pages5
JournalNeurochemical Research
Issue number10
StatePublished - Oct 1993
Externally publishedYes


  • Adrenal medulla
  • adrenal cortex
  • chromaffin cell
  • glycine
  • glycine receptor
  • strychnine


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