Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad; Nicola Luigi Bragazzi; Dennis McGonagle; Mohammed Adawi; Charlie Bridgewood; Giovanni Damiani; Jaume Alijotas-Reig; Enrique Esteve-Valverde; Mariana Quaresma; Howard Amital; Yehuda Shoenfeld

doi:10.1016/j.clim.2019.03.007

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abdulla Watad, Nicola Luigi Bragazzi, Dennis McGonagle, Mohammed Adawi, Charlie Bridgewood, Giovanni Damiani, Jaume Alijotas-Reig, Enrique Esteve-Valverde, Mariana Quaresma, Howard Amital, Yehuda Shoenfeld

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Clinical Immunology
Volume	203
DOIs	https://doi.org/10.1016/j.clim.2019.03.007
State	Published - Jun 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.

Funding

The authors declare no competing financial interests. This work is supported by the grant of the Government of the Russian Federation for the state support of scientific research carried out under the supervision of leading scientists, agreement 14.W03.31.0009 .

Funders	Funder number
Government Council on Grants, Russian Federation

Keywords

ASIA syndrome
Foreign material
International syndrome registry
Silicone breast implants
Vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2019.03.007

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Watad, A., Bragazzi, N. L., McGonagle, D., Adawi, M., Bridgewood, C., Damiani, G., Alijotas-Reig, J., Esteve-Valverde, E., Quaresma, M., Amital, H., & Shoenfeld, Y. (2019). Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. Clinical Immunology, 203, 1-8. https://doi.org/10.1016/j.clim.2019.03.007

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title = "Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases",

abstract = "Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.",

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author = "Abdulla Watad and Bragazzi, {Nicola Luigi} and Dennis McGonagle and Mohammed Adawi and Charlie Bridgewood and Giovanni Damiani and Jaume Alijotas-Reig and Enrique Esteve-Valverde and Mariana Quaresma and Howard Amital and Yehuda Shoenfeld",

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year = "2019",

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doi = "10.1016/j.clim.2019.03.007",

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Watad, A, Bragazzi, NL, McGonagle, D, Adawi, M, Bridgewood, C, Damiani, G, Alijotas-Reig, J, Esteve-Valverde, E, Quaresma, M, Amital, H & Shoenfeld, Y 2019, 'Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases', Clinical Immunology, vol. 203, pp. 1-8. https://doi.org/10.1016/j.clim.2019.03.007

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. / Watad, Abdulla; Bragazzi, Nicola Luigi; McGonagle, Dennis et al.
In: Clinical Immunology, Vol. 203, 06.2019, p. 1-8.

Research output: Contribution to journal › Article › peer-review

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T1 - Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype

T2 - Insights from an analysis of 500 cases

AU - Watad, Abdulla

AU - Bragazzi, Nicola Luigi

AU - McGonagle, Dennis

AU - Adawi, Mohammed

AU - Bridgewood, Charlie

AU - Damiani, Giovanni

AU - Alijotas-Reig, Jaume

AU - Esteve-Valverde, Enrique

AU - Quaresma, Mariana

AU - Amital, Howard

AU - Shoenfeld, Yehuda

PY - 2019/6

Y1 - 2019/6

N2 - Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

AB - Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.

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KW - Foreign material

KW - International syndrome registry

KW - Silicone breast implants

KW - Vaccines

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Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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