Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA

Yonatan Ganor; Hadassa Goldberg-Stern; Tally Lerman-Sagie; Vivian I. Teichberg; Mia Levite

doi:10.1016/j.eplepsyres.2005.03.011

Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA

Yonatan Ganor, Hadassa Goldberg-Stern, Tally Lerman-Sagie, Vivian I. Teichberg, Mia Levite

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

We studied 82 patients with different types of epilepsy and 49 neurologically intact non-epileptic controls, and identified three different subpopulations of epilepsy patients bearing significantly elevated levels of autoantibodies to either GluR3B-peptide of glutamate/AMPA receptor subtype 3 (17/82; 21% of patients), or to a peptide of NR2A subunit of glutamate/NMDA receptors (15/82; 18%), or to double-stranded (ds) DNA, the hallmark of systemic lupus erythematosus (13/80; 16%). Most patients had only one antibody type, arguing against cross-reactivity. Nearly all anti-dsDNA Ab-positive patients did not harbor anti-nuclear autoantibodies. Most patients had no history of brain damage, febrile convulsions, early onset epilepsy, acute epilepsy or intractable seizures. We suggest to measure the 'autoimmune-fingerprints' of epilepsy patients for diagnostic and therapeutic purposes.

Original language	English
Pages (from-to)	11-22
Number of pages	12
Journal	Epilepsy Research
Volume	65
Issue number	1-2
DOIs	https://doi.org/10.1016/j.eplepsyres.2005.03.011
State	Published - Jun 2005
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank Prof. Zvi Vogel and Prof. Yadin Dudai of The Weizmann Institute of Science, and Prof. Dov Lichtenberg, Dean of the Sadder Faculty of Medicine, Tel-Aviv University, for their important support and their constructive attitude that enabled this study to be performed. We also thank warmly Prof. Olivier Dulac (Paris) for his valuable and incisive comments on our manuscript. Special gratitude and appreciation go to Prof. David Steinberg, head of the Department of Statistics and Operations Research at the School of Mathematical Sciences, Tel Aviv University, for his rigorous statistical analysis and for his didactic comments. This study was supported by grants to Dr. M. Levite from Volkswagen Stiftung and CURE (USA) citizens United for Research in Epilepsy Inc.

Funding

The authors thank Prof. Zvi Vogel and Prof. Yadin Dudai of The Weizmann Institute of Science, and Prof. Dov Lichtenberg, Dean of the Sadder Faculty of Medicine, Tel-Aviv University, for their important support and their constructive attitude that enabled this study to be performed. We also thank warmly Prof. Olivier Dulac (Paris) for his valuable and incisive comments on our manuscript. Special gratitude and appreciation go to Prof. David Steinberg, head of the Department of Statistics and Operations Research at the School of Mathematical Sciences, Tel Aviv University, for his rigorous statistical analysis and for his didactic comments. This study was supported by grants to Dr. M. Levite from Volkswagen Stiftung and CURE (USA) citizens United for Research in Epilepsy Inc.

Funders	Funder number
Volkswagen Stiftung
Citizens United for Research in Epilepsy

Keywords

Antibodies
Autoimmunity
Double-stranded DNA (dsDNA)
Epilepsy
GluR3
Glutamate receptor
NR2A

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10.1016/j.eplepsyres.2005.03.011

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title = "Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA",

abstract = "We studied 82 patients with different types of epilepsy and 49 neurologically intact non-epileptic controls, and identified three different subpopulations of epilepsy patients bearing significantly elevated levels of autoantibodies to either GluR3B-peptide of glutamate/AMPA receptor subtype 3 (17/82; 21% of patients), or to a peptide of NR2A subunit of glutamate/NMDA receptors (15/82; 18%), or to double-stranded (ds) DNA, the hallmark of systemic lupus erythematosus (13/80; 16%). Most patients had only one antibody type, arguing against cross-reactivity. Nearly all anti-dsDNA Ab-positive patients did not harbor anti-nuclear autoantibodies. Most patients had no history of brain damage, febrile convulsions, early onset epilepsy, acute epilepsy or intractable seizures. We suggest to measure the 'autoimmune-fingerprints' of epilepsy patients for diagnostic and therapeutic purposes.",

keywords = "Antibodies, Autoimmunity, Double-stranded DNA (dsDNA), Epilepsy, GluR3, Glutamate receptor, NR2A",

author = "Yonatan Ganor and Hadassa Goldberg-Stern and Tally Lerman-Sagie and Teichberg, {Vivian I.} and Mia Levite",

note = "Funding Information: The authors thank Prof. Zvi Vogel and Prof. Yadin Dudai of The Weizmann Institute of Science, and Prof. Dov Lichtenberg, Dean of the Sadder Faculty of Medicine, Tel-Aviv University, for their important support and their constructive attitude that enabled this study to be performed. We also thank warmly Prof. Olivier Dulac (Paris) for his valuable and incisive comments on our manuscript. Special gratitude and appreciation go to Prof. David Steinberg, head of the Department of Statistics and Operations Research at the School of Mathematical Sciences, Tel Aviv University, for his rigorous statistical analysis and for his didactic comments. This study was supported by grants to Dr. M. Levite from Volkswagen Stiftung and CURE (USA) citizens United for Research in Epilepsy Inc. ",

year = "2005",

month = jun,

doi = "10.1016/j.eplepsyres.2005.03.011",

language = "אנגלית",

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Ganor, Y, Goldberg-Stern, H, Lerman-Sagie, T, Teichberg, VI & Levite, M 2005, 'Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA', Epilepsy Research, vol. 65, no. 1-2, pp. 11-22. https://doi.org/10.1016/j.eplepsyres.2005.03.011

Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA. / Ganor, Yonatan; Goldberg-Stern, Hadassa; Lerman-Sagie, Tally et al.
In: Epilepsy Research, Vol. 65, No. 1-2, 06.2005, p. 11-22.

Research output: Contribution to journal › Article › peer-review

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T2 - Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA

AU - Ganor, Yonatan

AU - Goldberg-Stern, Hadassa

AU - Lerman-Sagie, Tally

AU - Teichberg, Vivian I.

AU - Levite, Mia

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PY - 2005/6

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N2 - We studied 82 patients with different types of epilepsy and 49 neurologically intact non-epileptic controls, and identified three different subpopulations of epilepsy patients bearing significantly elevated levels of autoantibodies to either GluR3B-peptide of glutamate/AMPA receptor subtype 3 (17/82; 21% of patients), or to a peptide of NR2A subunit of glutamate/NMDA receptors (15/82; 18%), or to double-stranded (ds) DNA, the hallmark of systemic lupus erythematosus (13/80; 16%). Most patients had only one antibody type, arguing against cross-reactivity. Nearly all anti-dsDNA Ab-positive patients did not harbor anti-nuclear autoantibodies. Most patients had no history of brain damage, febrile convulsions, early onset epilepsy, acute epilepsy or intractable seizures. We suggest to measure the 'autoimmune-fingerprints' of epilepsy patients for diagnostic and therapeutic purposes.

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KW - Glutamate receptor

KW - NR2A

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Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA

Abstract

Bibliographical note

Funding

Keywords

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