Abstract
Asymmetric syntheses of piperidine alkaloids N-acetyl-(R)-coniine and (2R,6R)-trans-solenopsin were achieved utilizing stereoselective additions of allylphenylsulfone to chiral alkyl-N-sulfinylimines and ring-closing olefin metathesis.
Original language | English |
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Pages (from-to) | 2269-2276 |
Number of pages | 8 |
Journal | Tetrahedron Asymmetry |
Volume | 12 |
Issue number | 16 |
DOIs | |
State | Published - 13 Sep 2001 |
Bibliographical note
Funding Information:Support of this research by a grant from the US–Israel Binational Science Foundation and from the Marcus Center for Medicinal and Pharmaceutical Chemistry is gratefully acknowledged. We thank Professor A. I. Meyers for providing (S)-coniine·HCl as well as HPLC analysis of 12 and 13 , and Dr. H. E. Gottlieb for valuable help with NMR spectra.
Funding
Support of this research by a grant from the US–Israel Binational Science Foundation and from the Marcus Center for Medicinal and Pharmaceutical Chemistry is gratefully acknowledged. We thank Professor A. I. Meyers for providing (S)-coniine·HCl as well as HPLC analysis of 12 and 13 , and Dr. H. E. Gottlieb for valuable help with NMR spectra.
Funders | Funder number |
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United States-Israel Binational Science Foundation |