Asymmetric syntheses of piperidine alkaloids N-acetyl-(R)-coniine and (2R,6R)-trans-solenopsin were achieved utilizing stereoselective additions of allylphenylsulfone to chiral alkyl-N-sulfinylimines and ring-closing olefin metathesis.
|Number of pages||8|
|State||Published - 13 Sep 2001|
Bibliographical noteFunding Information:
Support of this research by a grant from the US–Israel Binational Science Foundation and from the Marcus Center for Medicinal and Pharmaceutical Chemistry is gratefully acknowledged. We thank Professor A. I. Meyers for providing (S)-coniine·HCl as well as HPLC analysis of 12 and 13 , and Dr. H. E. Gottlieb for valuable help with NMR spectra.