Asymmetric nitrogen 60. Acylation as a pathway to optically active 1,3,3-trisubstituted diaziridines

G. V. Shustov, S. N. Denisenko, M. A. Shokhen, R. G. Kostyanovskii

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

1. The acylation of 1,3,3-trisubstituted diaziridines with acyl chlorides is realized primarily at the substituted N1 atom and is accompanied by diaziridine-hydrazone rearrangement. 2. Acylation with a 0.5-mole amount of (S)-N-tosylproline chloride is an effective method for the optical activation of 1,3,3-trialkyldiaziridines and can be used to determine the absolute configurations of these compounds.

Original languageEnglish
Pages (from-to)1665-1671
Number of pages7
JournalBulletin of the Academy of Sciences of the USSR Division of Chemical Science
Volume37
Issue number8
DOIs
StatePublished - Aug 1988
Externally publishedYes

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