Asthma risk after a pediatric intensive care unit admission for respiratory syncytial virus bronchiolitis

Moria Be'er, Shai Bushmitz, Michal Cahal, Efraim Sadot, Sivan Yochpaz, Omri Besor, Israel Amirav, Moran Lavie

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Admission to a pediatric intensive care unit (PICU) has been associated with respiratory consequences in children with asthma and carries major implications for management control. Whereas respiratory syncytial virus (RSV) bronchiolitis has been associated with increasing intensity of wheezing, the relationship between RSV-bronchiolitis PICU admission and future asthma is unclear. This retrospective case-control study evaluated whether hospitalization in the PICU due to RSV bronchiolitis is more likely to be associated with future asthma in early life compared with hospitalization in a general pediatric ward. Methods: Children hospitalized due to RSV bronchiolitis between 2007 and 2019 in the PICU (study group) were compared to those hospitalized in a general pediatric ward (controls). Asthma prevalence was assessed by a follow-up questionnaire based on The International Study of Asthma and Allergies in Childhood questionnaire. Results: Sixty-three PICU patients and 66 controls were included. The PICU patients presented with more severe disease during RSV hospitalization. At follow-up, significantly more PICU patients aged 3–6 years had physician-diagnosed asthma, respiratory symptoms during the previous 12 months, and underwent respiratory treatment since hospital discharge compared to controls (14 [60.9%] vs. 4 [18.2%] patients; 15 [65.2%] vs. 6 [27.3%]; and 16 [69.6%] vs. 8 [36.4%]; respectively). These differences were no longer observed after 6 years of age. Conclusions: Children admitted to the PICU for RSV bronchiolitis are at higher risk for asthma in subsequent pre-school years and will require close respiratory follow-up than those admitted to general pediatric wards. Admission venue should be queried when asthma is suspected.

Original languageEnglish
Pages (from-to)1677-1683
Number of pages7
JournalPediatric Pulmonology
Issue number7
StatePublished - Jul 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.


  • asthma
  • intensive care unit
  • respiratory syncytial virus


Dive into the research topics of 'Asthma risk after a pediatric intensive care unit admission for respiratory syncytial virus bronchiolitis'. Together they form a unique fingerprint.

Cite this