Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study

H3 Africa Kidney Research Network

doi:10.1038/s41598-022-13740-x

Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study

H3 Africa Kidney Research Network

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.

Original language	English
Article number	10631
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-13740-x
State	Published - 23 Jun 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Funding

We acknowledge the role of the H3Africa Consortium in making this research possible though the sharing of data. The National Institutes of Health (USA) and Wellcome Trust (UK) have provided the core funding for the H3Africa Consortium. We thank the many MEND investigators who contributed substantially to the inception and design of the study, and the patients and families who participated in the MEND study for their vital contribution in advancing the science of cancer in Nigeria and globally. We acknowledge the important contribution of the MEND research nurses: Cordelia Ibeneme, Peju Olabanji, Rebecca Israel, Esther Akinwale, Deborah Awodeyi, and Shukurat Oduola. This research was specifically funded by National Institutes of Health, National Cancer Institute, Fogarty International Center (K01TW010271, T.A.), and National Institutes of Health (NIH 1P30DK124723-01). The views expressed in this paper do not represent the views of the National Institutes of Health, H3Africa Consortium or their funders.

Funders	Funder number
MEND
National Institutes of Health	1P30DK124723-01
National Cancer Institute
Fogarty International Center	K01TW010271
Wellcome Trust

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-13740-x

Cite this

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title = "Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study",

abstract = "There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.",

author = "{H3 Africa Kidney Research Network} and Anjali Gupta and Veeral Saraiya and April Deveaux and Taofik Oyekunle and Jackson, {Klarissa D.} and Omolola Salako and Adetola Daramola and Allison Hall and Olusegun Alatise and Gabriel Ogun and Adewale Adeniyi and Omobolaji Ayandipo and Thomas Olajide and Olalekan Olasehinde and Olukayode Arowolo and Adewale Adisa and Oludolapo Afuwape and Aralola Olusanya and Aderemi Adegoke and Tollefsbol, {Trygve O.} and Donna Arnett and Muehlbauer, {Michael J.} and Newgard, {Christopher B.} and Samuel Ajayi and Yemi Raji and Timothy Olanrewaju and Charlotte Osafo and Ifeoma Ulasi and Adanze Asinobi and Winkler, {Cheryl A.} and David Burke and Fatiu Arogundade and Ivy Ekem and Jacob Plange-Rhule and Manmak Mamven and Michael Mate-kole and Olukemi Amodu and Richard Cooper and Sampson Antwi and Adebowale Adeyemo and Titilayo Ilori and Victoria Adabayeri and Alexander Nyarko and Anita Ghansah and Amos-Abanyie, {Ernestine Kubi} and Akyaw, {Priscilla Abena} and Kimmel, {Paul L.} and Salako, {Babatunde L.} and Parekh, {Rulan S.} and Karl Skorecki",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jun,

day = "23",

doi = "10.1038/s41598-022-13740-x",

language = "אנגלית",

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T1 - Association of lipid profile biomarkers with breast cancer by molecular subtype

T2 - analysis of the MEND study

AU - H3 Africa Kidney Research Network

AU - Gupta, Anjali

AU - Saraiya, Veeral

AU - Deveaux, April

AU - Oyekunle, Taofik

AU - Jackson, Klarissa D.

AU - Salako, Omolola

AU - Daramola, Adetola

AU - Hall, Allison

AU - Alatise, Olusegun

AU - Ogun, Gabriel

AU - Adeniyi, Adewale

AU - Ayandipo, Omobolaji

AU - Olajide, Thomas

AU - Olasehinde, Olalekan

AU - Arowolo, Olukayode

AU - Adisa, Adewale

AU - Afuwape, Oludolapo

AU - Olusanya, Aralola

AU - Adegoke, Aderemi

AU - Tollefsbol, Trygve O.

AU - Arnett, Donna

AU - Muehlbauer, Michael J.

AU - Newgard, Christopher B.

AU - Ajayi, Samuel

AU - Raji, Yemi

AU - Olanrewaju, Timothy

AU - Osafo, Charlotte

AU - Ulasi, Ifeoma

AU - Asinobi, Adanze

AU - Winkler, Cheryl A.

AU - Burke, David

AU - Arogundade, Fatiu

AU - Ekem, Ivy

AU - Plange-Rhule, Jacob

AU - Mamven, Manmak

AU - Mate-kole, Michael

AU - Amodu, Olukemi

AU - Cooper, Richard

AU - Antwi, Sampson

AU - Adeyemo, Adebowale

AU - Ilori, Titilayo

AU - Adabayeri, Victoria

AU - Nyarko, Alexander

AU - Ghansah, Anita

AU - Amos-Abanyie, Ernestine Kubi

AU - Akyaw, Priscilla Abena

AU - Kimmel, Paul L.

AU - Salako, Babatunde L.

AU - Parekh, Rulan S.

AU - Skorecki, Karl

PY - 2022/6/23

Y1 - 2022/6/23

N2 - There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.

AB - There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.

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Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study

Abstract

Bibliographical note

Funding

UN SDGs

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