Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia

Mark Weiser, Araham Reichenberg, Jonathan Rabinowitz, Zeev Kaplan, Mordehai Mark, Ehud Bodner, Daniella Nahon, Michael Davidson

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background: Nonpsychotic psychiatric symptoms may occasionally herald the later development of schizophrenia. This study followed a population-based cohort of adolescents with nonpsychotic, non-major affective psychiatric disorders to ascertain future hospitalization for schizophrenia. Methods: Results of the medical and mental health assessments on 12424416- to 17-year-old males screened by the Israeli draft board were cross-linked with the National Psychiatric Hospitalization case registry, which contains data on all psychiatric hospitalizations in the country, during a 4- to 8-year-long follow-up through age 25 years. In the cohort, 9365 adolescents were assigned a nonpsychotic, non-major affective diagnosis by the draft board. Results: After excluding 167 adolescents who were hospitalized before or up to 1 year after the draft board assessment, 103% of the adolescents assigned a nonpsychotic, non-major affective psychiatric diagnosis, compared with only 0.23% of the adolescents without any psychiatric diagnosis, were later hospitalized for schizophrenia. Of the patients with schizophrenia, 26.8%, compared with only 7.4% in the general population, had been assigned a nonpsychotic, non-major affective psychiatric diagnosis in adolescence (overall odds ratio [OR], 4.5; 95% confidence interval [CI], 3.6-5.6), ranging from OR, 21.5 (95% CI, 12.6-36.6) for schizophrenia spectrum personality disorders to OR, 3.6 (95% CI, 2.1-6.2) for neurosis. Conclusion: These results reflect the relatively common finding of impaired functioning in patients later hospitalized for schizophrenia and the relatively low power of these disorders in predicting schizophrenia.

Original languageEnglish
Pages (from-to)959-964
Number of pages6
JournalArchives of General Psychiatry
Issue number10
StatePublished - 2001


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