Association between a common CYP17A1 haplotype and anxiety in female anorexia nervosa

Efrat Czerniak, Michael Korostishevsky, Amos Frisch, Yoram Cohen, Ninette Amariglio, Gideon Rechavi, Elena Michaelovsky, Daniel Stein, Yardena Danziger, Silvana Fennig, Alan Apter, Abraham Weizman, Eva Gak

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dehydroepiandrosterone (DHEA), the main brain neurosteroid, has been implicated in various psychiatric disorders especially those including gender differences. We studied genetic variability in the DHEA-producing enzyme CYP17A1 in relation to anorexia nervosa (AN) susceptibility and AN-related co-morbidities. We performed analysis of 100 Israeli AN family trios accounting for CYP17A1 haplotypes characteristic of populations of European origin and studied genotype-phenotype relationships using correlation analyses and transmission disequilibrium test. Although our analysis revealed no evidence of association between CYP17A1 and AN per se, it revealed an association between specific CYP17A1 haplotypes and AN co-morbidity, specifically anxiety. We found that a common CYP17A1 haplotype (H1) was associated with higher anxiety in AN patients (Clinical Global Impression; CGI-anxiety ≥4). Moreover, H1 homozygotes were at higher risk for expressing high CGI-anxiety levels (OR = 3.7), and H1 was preferentially transmitted to AN patients with high CGI-anxiety levels (P = 0. 037). We suggest that CYP17A1 H1 haplotype may contribute to genetic predisposition to higher CGI-anxiety levels in AN patients and that this predisposition may be mediated by reduced CYP17A1 enzymatic activity and corresponding lower DHEA production.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalArchives of Women's Mental Health
Volume16
Issue number5
DOIs
StatePublished - Oct 2013
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by the Israeli Ministry of Health Chief Scientist grant no. 3000003229 and made part of the M.Sc. thesis of Efrat Czerniak at the Department of Molecular Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University. We gratefully acknowledge the Assi Schneidman foundation for partial support of this study.

Keywords

  • Anorexia nervosa
  • Anxiety
  • CYP17A1
  • Haplotype
  • Neurosteroids

Fingerprint

Dive into the research topics of 'Association between a common CYP17A1 haplotype and anxiety in female anorexia nervosa'. Together they form a unique fingerprint.

Cite this