An attempt has been made to assess the pituitary response to the nasal application of synthetic gonadotropin-releasing hormone (GnRH) in three oligospermic and two azoospermic men. Intranasal administration of 3 mg of GnRH in aqueous or natural plant gum solution produced a pituitary response pattern similar to that produced by the intramuscular injection of 100 μg, with respect to plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). No technical difficulties or side effects were observed. GnRH in a nasal drop preparation seems to be effective in releasing LH and FSH in men. These findings may have a practical application in those cases where longterm therapy with the hormone is indicated.
|Number of pages||5|
|Journal||Fertility and Sterility|
|State||Published - 1977|
Bibliographical noteFunding Information:
This investigation was supported by grants from the Swedish Medical Research Council (grant 2028) and the WHO Expanded Programme of Research, Development and Research Training. The authors thank Ms. L.M. Lindeholm for her assistance in the preparation of the manusc_ript.